CONGENITAL FIBRINOGEN DISORDERS AND GENETIC MUTATIONS

Abstract

Congenital fibrinogen disorders (CFD) are a group of diseases that are quite rare. According to clinical manifestations, the following forms of fibrinogen dysfunction are distinguished: quantitative changes (afibrinogenemia and hypofibrinogenemia) and qualitative changes (dysfibrinogenemia and hypodysfibrinogenemia) [1, P.90]. Type I disorders (afibrinogenemia and hypofibrinogenemia) affect the amount of fibrinogen in the blood (fibrinogen levels below 1.5 g/l). Type II disorders (dysfibrinogenemia and hypodysfibrinogenemia) affect the quality of circulating fibrinogen [4].