EVALUATION OF THE EFFICACY OF ARTERIAL HYPERTENSION THERAPY IN ELDERLY PATIENTS

Abstract

Comorbidity and arterial hypertension and type 2 diabetes mellitus are distinguished by the common pathophysiological mechanisms of development, as well as similar mechanisms of a high risk of developing cardiovascular complications. This relationship is due to the activation of the renin-angiotensin-aldosterone system, which underlies the progression of remodeling of the cardiovascular system and the development of complications. An important link in the effective treatment of this pathogenetic comorbidity, according to modern clinical guidelines, is the blockade of the activity of the renin-angiotensin-aldosterone system using, in particular, angiotensin-converting enzyme inhibitors. This article presents the results of a clinical study on the effectiveness of combination therapy (ramipril and hydrochlorothiazide) in older patients with arterial hypertension and diabetes mellitus.