SYMPTOMS OF OVARIAN GRANULOSA CELL TUMORS ASSOCIATED WITH THEIR HORMONE PRODUCTION IN ADULT AND YOUNG PATIENTS IN THE ANDIZHAN REGION

Abstract

After studying various types of ovarian tumors, the authors determined that granulosa cell tumors (GCT) are the most common among hormone-producing ovarian neoplasms, accounting for 2-7.5% of all ovarian tumors and 85% of all hormone-producing ovarian tumors according to various authors. In their lectures, Davydov M.I. and other scientists note that most GCTs produce steroid (estrogens, less frequently progesterones and androgens) and glycoprotein (inhibin, Müllerian inhibiting substance) hormones, leading to menstrual cycle disturbances such as hyperpolimenorrhea, amenorrhea with subsequent acyclic bloody discharge or bleeding, and the development of rejuvenation hormonal symptoms. Thanks to such a vivid clinical picture, the disease is diagnosed in 90% of patients at stage I. At the same time, there are reports in the literature of hormonally inactive GCTs, which, according to some authors, indicate a high degree of cell anaplasia in the neoplastic cells and a poor prognosis.